Whole plant medicine has been widely debated as many states consider limited legalization of cannabinoids like CBD, and the idea that the entourage effect is integral to using cannabis as medicine is increasingly accepted. In fact, some products are being designed specifically to maximize the value of whole plant medicine for the consumer. Take Firefly’s vaporizer technology, which sets out to capture all the myriad benefits of the entourage effect through dynamic convection technology. “[Firefly 2 was] truly designed around the plant…in order to deliver all the cannabinoids and terpenes in the most efficient way,” says Rachel Dugas of Firefly. Yet given the complexities of these chemical interactions, it’s still hard to pin down how exactly this maximizes the benefits of cannabis.
What the Experts Say About CBD’s Effects and Benefits
To shed some light on the subject, we assembled a panel of five experts in different areas of the cannabis space to weigh in:
- Jessica Peters (founder, Moxie Meds);
- Constance Finley (founder and CEO, Constance Therapeutics);
- Mary Lynn Mathre RN, MSN (president and co-founder, Patients Out of Time);
- Eloise Theisen RN, MSN (director, American Cannabis Nurses Association);
- Perry Solomon, MD (chief medical officer, HelloMD).
Here’s what they had to say.
What effects does CBD have on its own?
Mary Lynn Mathre: “Many – anxiolytic, anti-inflammatory, anti-seizure, neuroprotective, bone stimulant, anti-spasmodic, and more.”
Jessica Peters: “Anti-inflammatory, anti-spasmodic, anti-proliferative, analgesic, anxiolytic (anti-anxiety), neuroprotective, anti-psychotic, anti-emetic (anti-nausea) … I can technically answer what are the properties of CBD, but these properties might not pop out if THC is not present. A potential new research category that I’ve seen evidence of anecdotally are addiction-fighting properties … CBD seems to reroute those neural pathways.”
Constance Finley: “Studies have shown CBD to have a positive effect on inflammation, pain, anxiety, psychosis and spasms, but it should be noted that most of these applications are not treated with just CBD alone and in fact do require some level of THC, whose role as a phytotherapeutic compound has already been established vis-à-vis many of the same conditions. CBD acts on different receptors than THC in the body.”
Perry Solomon: “It’s been found that CBD alone can cause a feeling of calm, relaxation. CBD’s other medicinal effects stem from completely separate pathways, such as the cannabinoid receptor 2 (CB2), mu and delta opioid receptors. Taken on its own, CBD has sedative, antioxidant, anti-anxiety, and antidepressant effects on the brain, but does not create any overtly psychoactive high like THC. It’s also been shown to have change gene expression and remove beta amyloid plaque, the hallmark of Alzheimer’s, from brain cells.”