One of more than 80 active cannabinoids in the Cannabis plant, CBD does not produce euphoria or intoxication, and has a very low affinity for CB1 and CB2 receptors when compared to THC (100 times less than tetrahydrocannabinol). Cannabidiol is a cannabinoid that interacts mildly with the endocannabinoid system, and acts as an antagonist for substances that do bind to the CB1 and CB2 receptors, activating them and causing biological responses. The term “antagonist” refers to a compound that inhibits or dampens the functions of a receptor, while agonists are chemicals that bind to receptors and active them. Being an antagonist, CBD doesn’t activate the receptors directly, but it helps other cannabinoids to be better absorbed and keeps the receptors working effectively. Below is the second half of the ultimate benefits list that CBD oil can bring you and your health.
- CBD may also be effective in treating mood disorders, anxiety and depression, as it possesses anxiolytic properties and inhibits stress and anxiety without causing psychoactive effects. Some studies suggest that the compound may be a viable treatment for patients with generalized anxiety disorder thanks to its action on the limbic and paralimbic brain areas. Brazilian researchers have found a rapid onset of therapeutic effects in SAD patients treated with a single dose of CBD, the compound exerting no psychoactive action and being well tolerated.
- The compound seems to help protect the brain and may be a suitable solution for treating neurodegenerative disorders, studies suggest. In patients with neurodegenerative disorders, the loss of nerve cells leads to a decline in cognitive and motor functions, and it is believed that inflammation plays a role in the progressive nature of neurodegeneration. The anti-inflammatory properties of CBD and the lack of psychotropic effects may recommend this substance as a promising agent for a wide range of neurodegenerative diseases.
- According to researchers from the University of California – Irvine, CBD seems to help in treating certain psychotic symptomsand may be a potential solution for patients affected by schizophrenia. The compound has been found to be superior to conventional antipsychotic medications, has fewer side effects and is more cost-effective than most of the available medications, scientists say. German researchers found that cannabidiol seems to work better than medications onschizophrenia’s “negative symptoms”, which are difficult to treat, and doesn’t cause weight or movement problems, as often happens with other drugs.
- A controlled animal study conducted by Italian researchers showed that topical application of cannabinoid-rich creams may help in reducing the brain damage caused by autoimmune encephalomyelitis. The mechanisms that cause this disease are similar to those that lead to multiple sclerosis in humans (damage to the myelin in the central nervous system), so scientists concluded that CBD could be used in the clinical management of multiple sclerosis and its associated symptoms, in association with current conventional therapy.
- Another animal study found that the administration of cannabidiol may be useful in reducing the damage caused byintervertebral disc degeneration. At the same time, research suggests that CBD may be the first non-toxic exogenous agent effective in killing breast cancer cells. Cannabidiol may be a viable addition to epilepsy treatments, and may block the formation of plaques in the brain that favor the occurrence of Alzheimer’s disease.